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“We believe unapproved quinine products represent a serious health risk because of the widespread use of this product for treating leg cramps. The development of more effective alternatives such as quinacrine, chloroquine, and primaquine in the twentieth century reduced the reliance on quinine. Because malaria is life-threatening, the risks associated with quinine use are justified for that condition. Quinine needs to be dosed carefully, and FDA-approved labeling reflects the fact that the risks associated with the use of this drug for treatment of leg cramps outweigh the benefits. I drink a glass of club soda with quinine in it. In 8 women who delivered live infants 1 to 6 days after starting quinine therapy, placental cord plasma quinine levels were between 1. These drugs may increase the risk of hypoglycemia by enhancing insulin sensitivity (ACE inhibitors, fibrates, ginseng); stimulating insulin secretion (salicylates, disopyramide, quinine, quinidine, MAOIs, ginseng); increasing peripheral glucose utilization (SSRIs, insulin-like growth factor); inhibiting gluconeogenesis (SSRIs, MAOIs, insulin-like growth factor); slowing the rate of gastric emptying (amylin analogs); and/or suppressing postprandial glucagon secretion (amylin analogs). Quinine is approved for treatment of malaria, but is also commonly prescribed to treat leg cramps and similar conditions. However, there is only one quinine product approved by the FDA. If you are or will be breast-feeding while you use Quinine Capsules, check with your doctor. There is also the potential for serious interactions between quinine drugs and other drugs, and there are conditions under which quinine should not be used. The agency urges consumers who are using quinine products and have questions or concerns to contact their health care provider.

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