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Disulfiram-induced hepatitis appears to be due to hypersensitivity, although extrahepatic signs of hypersensitivity are not always apparent. The "disulfiram reaction" generally occurs within 15 minutes of ingestion of alcohol and persists as long as alcohol is present in the system. Liquid sertraline may contain alcohol and you could have a severe reaction to the disulfiram. Disulfiram reactions may occur up to two weeks after disulfiram has been discontinued. The ingestion of alcohol in patients pretreated with disulfiram generally results in an unpleasant reaction referred to as a "disulfiram reaction". Though no similar reactions have been reported with tinidazole, tinidazole should not be given to patients who have taken disulfiram within the last two weeks. While no disulfiram-like reactions are associated with cefonicid, they are theoretically possible based on the chemical structure of the drug. This has progressed to seizures (in the absence of a disulfiram-alcohol reaction), psychosis, catatonia and encephalopathy. Delirium has been reported with concurrent administration of Amitriptyline and disulfiram. Subcutaneous deposits of carotene which simulate jaundice has been reported in a 55-year-old man who presented with yellow palms of the hands and the sole of the feet within 2 months of the start of disulfiram. Patients should not receive disulfiram until 12 hours after any alcohol ingestion.

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